① Heart Disease
Pathogenic bacteria present in oral biofilms, such as *Porphyromonas gingivalis*, can easily enter the bloodstream when gums are chronically inflamed. Once inside the bloodstream, they can attach to the vascular endothelium or arterial plaques, triggering a local inflammatory response. This chronic inflammation may not only accelerate the formation of atherosclerosis but also increase the risk of vascular blockage, thereby increasing the incidence of cardiovascular events such as myocardial infarction or stroke. Multiple epidemiological studies have shown that patients with periodontitis have a significantly higher risk of heart disease than those with healthy oral cavity, suggesting that oral biofilms, through inflammation and bacterial transmission mechanisms, may be an important risk factor for heart disease. Therefore, controlling oral biofilms and maintaining healthy gums are also considered as adjunctive measures for preventing cardiovascular disease.